Antipyretic actions of human recombinant lipocortin-1
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چکیده
منابع مشابه
Human recombinant lipocortin 1 has acute local anti-inflammatory properties in the rat paw edema test.
Human recombinant lipocortin 1 has been tested for anti-inflammatory activity in a conventional model of acute inflammation. Microgram amounts of the protein, locally administered, inhibited edema of the rat paw when induced by subplantar injections of carrageenin: the ED50 was 10-20 micrograms per paw, and inhibition (maximum of 60-70%) was not dependent upon an intact adrenal cortex. Doses of...
متن کاملExpression of human recombinant lipocortin I in a wheat-germ cell-free system and Xenopus oocytes. Lipocortin is not secreted.
Lipocortin I has been presumed to be synthesized and secreted in response to glucocorticoids yet the amino acid sequence of lipocortin I reveals no signal sequence typically necessary for proteins to enter the secretory pathway. The translocation of lipocortin I across membranes was analyzed in a cell-free system and in Xenopus oocytes. Based on the published sequence, the cDNA of human lipocor...
متن کاملAutoantibodies to recombinant lipocortin-1 in rheumatoid arthritis and systemic lupus erythematosus.
Corticosteroids may mediate some of their anti-inflammatory effects via induction of a specific 38 kD protein, lipocortin-1. Autoantibodies to lipocortin-1 were measured by enzyme linked immunosorbent assay (ELISA) in 90 healthy subjects and in 63 patients with rheumatoid arthritis (RA), 36 with systemic lupus erythematosus (SLE), 26 with polymyalgia rheumatica, and 13 with chronic airways dise...
متن کاملImpairment of erythrocyte-antibody rosette formation by human lipocortin 1 on human leucocytes
clonotype appeared at weeks 15-16 (tracks B2 and C3) and then died away. Rats D and E had biclonal spectrotypes at weeks 12 and 16, respectively (tracks D3 and E4). The acidic clonotype of rat E was replaced by a new one at 27 weeks (track E6). Similar changes occurred in the spectrotype of rat F, a dominant group of basic bands appearing at 20 weeks (track F5) to be replaced in turn by a clono...
متن کاملLipocortin 1: glucocorticoids caught in the act?
Glucocorticoids (glucocorticosteroids, corticosteroids) have an important place in the treatment of many inflammatory conditions including those of the respiratory tract. Their mechanisms of action include both the suppression of proinflammatory mediators and the upregulation of at least one anti-inflammatory protein, lipocortin 1 (also known as annexin 1). Lipocortin 1 has been convincingly de...
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ژورنال
عنوان ژورنال: British Journal of Pharmacology
سال: 1991
ISSN: 0007-1188
DOI: 10.1111/j.1476-5381.1991.tb12122.x